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The Hand-Feet of a Hamster

Talked to a friend today who was having a tough time with a cyclical issue that consistantly returns surrounding her career.  A huge amount of work spent towards an overwhelming accomplishment that she succeeds to pull off while those surrounding her tend to get the credit and the reward.  When something is so cyclical and recurring there is no denying that you are creating it, that you in some way have decided that this is how it will be and until you understand the crappy agreement you have allowed yourself to settle for, the contract you have made with yourself to say… ‘Yes, this is how it’ll be for me… I’ll take it.’  You will continue to succeed at fulfilling this unconsciously accepted goal.  You may not want it or like it in any manner and wish so desperately for it to be different, but that is irrelevant as you have scarred yourself with this subconscious tattoo that will continue to live on inside of you.The conversation started with that customary greeting of ‘how’s it going’ and was responded to with that response that we tend to hear so often.  

“Same shit.”

A few reaffirming sentences validate the commraderie of living in that state.  

“Same shit, just a different pile” as another friend said to me the previous day.  Somehow that quickly stimulated something along the lines of… “Like a hamster on a treadmill.”  And then it hit me.

The feet of a hamster seem more like hands, don’t they?  Kind of?  The hamsters I remember holding years ago seemed to have long, lanky toes that were more like stiff little fingers.  I started imaging those little hand-feet (we’ll call them) having to grab onto whatever it was that they were walking on, with every step.  Then I began to realize that those spinning wheels that they run on are not your average treadmill, as they are generally constructed with lots of cross bars instead of a flat surface.  A human running on a treadmill just clomps along, thoughtlessly pounding upon the spinning surface, but for a hamster it’s not so simple.  They don’t have big flat soles pushing the bars of their treadmill, but instead their little hand-feet have to grab onto each passing bar with meticuluous precision again and again and again without allowing their legs to fall between the cracks.  And those bars are generally not moving slowly, usually you can feel the winds a few feet from the cage.  Not only that, but the bars are passing within an inch of their eyes, distorting and blurring anything in front of them.  It’s an extremely demanding task on the hamster’s entire being…  imagine it… It’s like if you were forced to cross a mile long river hanging from monkey bars that were actually train tracks and the train was just behind you forcing you to travel at the speed of an amphetamine.

Grab… grab… grab… grab, grab, grab, grabgrabgrabGRABGRABGRABGRABGRABGRABGRABGRABGRAB…  and you can’t see shit, but you don’t feel safe closing your eyes.  Focus, focus, focus… the world is spinning in front of you, precision grabs, don’t slip, don’t let up or you’re fucked… and… whew… nice one.  Let’s go stick our nose on this metal ball over here so some water can spill on my face and I’ll try to swallow a bit of it before it gets dried up by the chemically-manufactured bits of crap they’ve covered my floor with making it so I can’t see where to avoid walking on all the shit I’ve made over the past four days since they last cleaned my cage.

I think these hamsters may not be getting the credit they really deserve.  Honestly, at the end of the day, how often do you hear people commending hamsters for what they go through?  But then again, at the end of the day… they are just hamsters.


The Life of Lithium

Here are a few stories from some of the research I’ve done surrounding the documentary I’ve been working on called ‘Shrink Me’ about the use of pharmaceutical drugs for mental stability.

Okay, so… since Lithium is pretty much the oldest drug used as a mood stabilizer I guess we should give it the respect it deserves and get to know it just a touch before ingesting it, right?  Now, I should make it clear that these history lessons should be thought of more as lesions than lessons, as I don’t have a research team working with me at the moment and I only have so much patience cross checking information… but here we go…

 At the end of the 1700s, the miners and the scientists came out of the ground with a mineral called petalite which contained Litium, however it wasn’t isolated to stand independently on it’s own until the early 1800s when electrolysis was imposed upon what is now known as lithium oxide.  And just to clarify, these Swedish scientists were not attempting to remove the hair from these minerals as these fall into the category of non-hair-growing minerals, and this form of electrolysis is when you stimulate decomposition by introducing the liquid or solid to an electric current.  Hello electricity… Hello what is now called Lithium Oxide, since we have not yet isolated Lithium… Let’s meet up and make Lithium cause maybe it’ll help people with their manic moods… and so here we are.

Before we get too far with this, I feel like I should mention that there is also a company called Lithia Springs Mineral Water who claim that in the mid-1800s the spring that they pull water from was used by a few doctors because of it’s high lithium content to treat alcoholism, opium addiction and other key issues that I’m hoping to face at some point in the near future, so I suppose I should hurry and get my order in when they start accepting them this summer.

Now, the real clincher of exciting knowledge… Lithium comes from the Greek word ‘lithos’ which means ’stone’ seeing as it was the only element in Group 1 of the periodic table that was from a mineral, where the other two common elements, sodium and potassium were discovered from plant sources.  The only thing more exciting than that is that Lithos is also a typeface made to resemble the geometric letterforms of Ancient Greek engravings and an article I found written in that typesetting went on to discuss the views that Ancients Greeks (or at least some of them) had towards mental illness, and a good majority of them viewed it as possession from evil spirits and used exorcism, which in some instances used physical beatings in attempts to drive the spirits away.  That said… would it be safe to say that one way to view Lithium nowadays might be that your psychiatrist has tossed you a stone to throw at your demons?

So then, from what I gather… our scientists got to work and throughout the late 1800s used lithium to treat a number of issues because they found it was effective at breaking down uric acid.   The most common disease being doused with miniscule bits of lithium at the time was gout, a disease where your body cannot properly metabolize uric acid, causing arthritis in the smaller bones in your feet (but not limited to those bones).  Uric acid was the Serotonin of it’s day in a way (popularity, I mean) and was blamed for many disorders, one of those being manic depression.  Apparently, a few doctors began using lithium to treat ‘mania’ throughout the 1870s, (mania being the manic state of bipolar disorder) as it seemed to sedate the patient from experiencing these hyper-enthusiastic states of sweaty-forehead coated euphoria.  So, on the one hand, lithium was being used to treat arthritis in the body and on the other, trying to induce arthritis in the mind.  Seeing that the pharmaceutical industry couldn’t patent that gentle little silvery-white metal known as atomic element #3, a significant budget was never spent on research and lithium began suffering from abandonment issues of it’s own until the mid 1900s.  

In 1949, John Cade so couragously began using extracts from pee that he took from schizophrenic patients and injecting it into rodents hoping to isolate the culprit agent that was causing that socially unacceptable behavior.  In experiments such as these, do you think that in order to see if one specific rodent seems to detach from reality to embrace a delusional, fantasy driven world, do you first need to spend time getting to know the rodent in order to properly observe the transformation?  If not, how do you truly gauge the schizophrenia they are acquiring from the pee injections?  And if they do seem upset, could it be justified that most anyone might get upset if someone was peeing IN them.  Unfortunately, Cade didn’t succeed at transforming the rodents’ ideological perception of themselves, but he did confirm that an isolated lithium ion tranquilized the rodents, and that was that.  He began treating hospitalized patients and published the first paper to be written on the use of lithium in the treatment of acute mania.  In 1970, the use of lithium was actually approved by the Food and Drug Administration, regardless of the fact that no one really knew why it worked.  That didn’t come until 1998.  

Researchers based out of the University of Wisconsin came to the conclusion that lithium promoted glutamate stabilization.  What is glutamate?  A key molecule in cellular metabolism.  Without getting too far gone with tons and tons of information, for now just think of it as this… glutamate needs to travel through the brain from neuron to receptor to keep things functioning nicely.  Too much glutamate between neurons gives you mania, too little gives you depression.  Lithium helps regulate and stabilize this, like a car wash for the roadways, only the suds seem to bind the car to the middle lane.  Or at least, that’s what everything seems to say.  Personally, I can’t confirm any of this as I haven’t started taking it yet, but it’s coming and the more I learn about it, the more my nerves seem to sputter and splinker and splunket.  Lots of unfeigned sp-ing.  Sort of like that nervousness you feel when the hooker jumps off from her straddle and rips the condom off of you, screaming out with earnest passion… ‘I just want to feel you’.  There’s an underlying fear-engulfed excitement, but the ambiguity of what’s to come slightly inhibits the enjoyment of your otherwise harmonious union.  Or at least, something close to that.

There are a lot of warnings and side effects and ’causes of death’ (more in the early life of the drug) that have occurred, but there are also a lot of success stories, so who would want to miss out on those odds?  You are supposed to have blood tests and thyroid tests and a few other tests before using it, and then again every few months being on it.  Did my psychiatrist demand that I do that prior to taking it?  Of course not.  Did yours?  How often do they?  Sadly, the inconvenience of taking the blood test would put off most people from taking the drug and is it really worth the risk of losing another taker who will most definitely be successfully sedated from that awful state of mania?  I have to stop now, I’m prematurely judging and my banter is just that until I have proven different by putting some time in on the drug.  Start soon.  Can’t Wait?

 


The Myth of Serotonin – The Birth of Prozac

 

Day 20

Jesus Christ… I can’t even remember to take the f***ing pill.  Each day it seems to grow further and further away from my memory regardless of the fact that I’m consumed with a project surrounding taking the damn things.  It seems that once tasks pass over that initial ‘new’ phase, they quickly fall into the category of regulatory day-to-day tasks that I have very-little-to-no desire to do.  It’s not even that I have a simple lack of desire, it’s that my awareness blocks it out so intensely that it becomes a non-existent task within my day.  Anything regular seems to be disregarded and avoided as I am constantly in search of something new and whatever the new thing seems to be within a given day, is the thing that I am focused and impassioned about.  This would work to some degree in a time where my only responsibility was to bring in fish for the family or if I was satiated in an adundance of such wealth that thoughtlessness was supported, but now in this reality.  In this reality, it is unacceptable, unattractive, unimpressive, un-, un-, un-…ethical even?

Anyway, I jumped up and threw 1000mg into my mouth for the fourth or fifth time and started the day slowly.  Motorcycle ride down to the Coffee Bean.  An hour of reading and writing and I came upon some amazing stories about the insignificant research that was done in the 60s which spawned the whole idea that Serotonin was a key component to mood stability or even worse… happiness.  Not sure what your take on Serotonin is, but my uneducated idea of it was that it was the chemical the brain secretes that stimulates the feeling of happiness, the thing that Ecstasy stimulates and Prozac regulates.  

That’s what my take on it was, but without going into heavy detail, the Serotonin theory was placed on the map in the early 60s which came from a book called ‘Recognizing the Depressed Person’.  The research done was quite minimal, however in the 50s they found that a drug called Marsilid was not only helping the lungs of tuberculosis patients, but also helping their heads.  They were apparently dancing in the halls with a euphoric joy and no one understood why.  They spent some time trying to understand what the Marsilid was doing and came to the conclusion that it was preventing the brain from secreting the enzyme responsible for breaking down Serotonin.  What was Marsilid… a derivitive of hydrozine…  What was hydrozine… a volatile alkaline liquid used in WWII to fuel German V-2 rockets, as well as, to make Marsilid for the patients at Sea View Hospital in New York.  

This stimulated the drug companies to go after the idea that mental illness of this sort might actually be a chemical imbalance instead of a psychological issue and Merck bought 50,000 copies of the book to distribute throughout the prescribing doctors.  In the meantime, they got to work on the Serotonin theory, which a very simplified version could be as follows… Serotonin was thought to act as a connector between the neural transmitters in the brain and the receivers around the brain and body.  The potential issue was that, in some people, a part of the brain cell known as the ‘reuptake pump’ was overactive with it’s capacity to clean up the available serotonin, leaving the receptors understimulated, leaving the person… depressed.  Possible solution… find a way to leave the serotonin there.  How did they go about it?  You don’t want to know… it’s vile and prehistortic and well…  basically, they injected rats with potential agents that might inhibit the serotonin absorption.  At which point, they would grind up and blenderize the rat’s brain hoping to find an agent that caused the left the serotonin alone and they did.  What was it?  Prozac.  And that was that… our nation was well on it’s way to becoming a society hopeful for an answer that would relieve them from taking responsibility for themselves.  But my God… if you can’t even remember to take the pill, is there actually any hope?  I guess that’s where the ADD comes in?  Technically, shouldn’t I be taking that pill first so that I can remember to take care of myself in all the other ways?

Over the past 50 years since the initial findings, research has increased but I’m not finding anything so significant based on much but projection.  The interesting thing is that all of natural medicine seems to follow in the footsteps of these findings and approaching them with their own techniques… but are they going for the proper core… which opens up the question that is far greater than we really want to open at this point… how much is about chemistry and physiology and how much is about mental strength and discipline?  Which leads to improper training of our minds and so on and so on… for now, let’s just pretend that maybe there is actually something to this medicine idea, just as the people dancing in the halls were experiencing from the rocket fuel they were ingesting.  There must be something to it… somehow… in some way.

Alright, I know that was a lot of information and not necessarily fun, so… I’m gonna leave you with just that for today, but on a personal note.  Can’t say there is any progress over here…  I’m still sort of a flatline… there is a bit of blockage on experiencing that bright, glowing drive that I sometimes have for life… everything is sort of acceptable… which in my opinion is unacceptable.  The spark in me is something I want and makes me feel alive and I will tough out this experiment, though there is a sensation of guilt in me that feels like I am sort of failing myself in certain ways by spending time inside of these illusory boundaries that I seem to be swimming within.

 


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